AstraZeneca in-licenses STING inhibitors from F-Star in a $300 million deal
Astrazeneca gets the global rights to research, develop and commercialize protein stimulator of interferon genes, STING inhibitor compounds, from F-star Therapeutics. Astrazeneca is responsible for currently preclinical STING inhibitor compounds from F-star, which retains rights to all its STING agonists in clinical development for treating cancer.
Astrazeneca has not named the indications it intends to target but said it plans to develop therapies across “immune-mediated diseases.” F-star is eligible for up to $12 million in up-front and near-term payments as well as for development and sales milestone payments of more than $300 million, plus single digit percentage royalty payments. F-star’s STING assets came from a reverse merger conducted with Spring Bank Pharmaceuticals that began in July 2020.
BioNTech acquires neoantigen TCR therapy platform from Kite
BioNTech and Kite, a Gilead Company announced the two companies have entered into a purchase agreement for BioNTech to acquire Kite’s solid tumor neoantigen TCR R&D platform and clinical manufacturing facility in Gaithersburg, MD. The acquired Gaithersburg facility will provide production capacity to support clinical trials in the US and will complement BioNTech’s existing cell therapy manufacturing facility in Idar-Oberstein, Germany.
The facility will support the development of BioNTech’s expanding pipeline of novel cell therapies, including cancer product candidates based on its CAR-T Cell amplifying mRNA vaccine (CARVac) and NEOSTIM platforms as well as the newly acquired individualized neoantigen TCR program. Kite will receive a one-time upfront payment from BioNTech to purchase Kite’s individualized solid tumor neoantigen TCR discovery platform as well as the Gaithersburg R&D and clinical manufacturing facility. Financial terms were not disclosed.