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Roche pays $250 million to get PD-1 regulated IL-2 program from Good Therapeutics

SOTIO Biotech

12/10/2022 | 3 minuty čtení

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ACQUISITIONS

Good Tx announced acquisition of conditionally active PD-1-regulated IL-2 program by Roche

Good Therapeutics, a privately held company, today announced it has entered into a definitive merger agreement to be acquired by Roche. With this acquisition, Roche will gain rights to Good Therapeutics’ innovative, conditionally active, PD-1-regulated IL-2 program and an exclusive right to the platform technology for the development of PD-1-regulated IL-2 receptor agonist therapeutics. Under the terms of the merger agreement, Roche will make an upfront cash payment of $250 million for the shares on a fully diluted basis and additional payments based on the achievement of predetermined development, regulatory, and commercial milestones. The transaction is conditioned upon clearance under the Hart-Scott-Rodino Antitrust Improvements Act and is expected to close in the third quarter of 2022. Following the close of the Roche acquisition, the Good Therapeutics team plans to apply the technology for the design of conditionally active therapeutics to other targets in immuno-oncology and beyond in a new company, Bonum Therapeutics.

PARTNERING

Seagen and Zai Lab entered a license agreement for Tivdak in greater China

Zai Lab and Seagen announced an exclusive collaboration and license agreement for the development and commercialization of Tivdak (tisotumab vedotin-tftv) in mainland China, Hong Kong, Macau, and Taiwan. Tivdak is the first and only ADC approved in the U.S. for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy. Seagen will receive an upfront payment of $30 million, as well as development, regulatory, and commercial milestone payments, and tiered royalties on net sales of Tivdak in the Zai Lab territory. Based on the existing Tivdak co-development and co-commercialization collaboration between Seagen and Genmab, all upfront, milestone payments, and royalties will be shared 50/50 with Genmab. In 2021, FDA granted accelerated approval for Tivdak for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy. As verification and description of clinical benefit in the US, and to support further global regulatory applications, a confirmatory phase 3 open-label, randomized, global clinical trial, innovaTV 301, is ongoing.

Arsenal Bio announced joint discovery collaboration with Genentech in T cell therapy space

Arsenal Biosciences, a privately held programmable cell therapy company engineering advanced CAR T therapies for solid tumors, today announced a multi-year collaboration with Genentech. The companies will deploy ArsenalBio’s proprietary technology for high-throughput screening and engineering of T cells, to identify critical success circuits in T cell-based therapies. This discovery process employs the convergence of automation, large-scale genome engineering with high-content profiling, and cutting-edge machine learning and artificial intelligence algorithms to aid and advance the design, building, and testing of next-generation cell therapies for cancer. Arsenal will receive $70 million in upfront payments along with research, development, and commercial milestones. Under the terms of the collaboration, ArsenalBio and Genentech will deploy synergistic capabilities to study effective T cell-based modifications and develop new understandings of their effects through preclinical analysis. Both companies will leverage these learnings in the development of future therapeutic candidates.

Scribe and Sanofi to collaborate on CRISPR-based cell therapies for cancer

Scribe Therapeutics, a molecular engineering company pioneering a CRISPR by Design platform for genetic medicine, announced a strategic collaboration with Sanofi for the use of Scribe’s CRISPR genome editing technologies to enable genetic modification of novel NK cell therapies for cancer. The agreement grants Sanofi non-exclusive rights to Scribe’s proprietary CRISPR platform of wholly owned enzymes to create ex vivo NK cell therapies. Scribe’s suite of custom engineering genome editing and delivery tools called CasX-Editors (XE), based on novel foundations such as the CasX enzyme, will support Sanofi’s expanding pipeline of NK cell therapeutics for oncology.

Overview of transactions in oncology (values in m$)

Source

Partner

Product

Stage

Rights

Value

UF

MS

Seagen

Zai Lab

License to Tivdak tisotumab vedotin, an ADC targeting TF using Seagen’s technology, approved for ovarian cancer

Market

CN,HK, TW,MC

293

30

263

SpringWorks Therapeutics

GSK

License to nirogacestat, oral selective small molecule gamma secretase inhibitor against desmoid tumors

Ph 3

WW

850

300

550

Nerviano Medical Sciences

Merck KGaA

Option to license to small molecule inhibitor of PAPR1 NMS-293 developed against BRCA-mutated tumors

Ph 1

WW

NA

65

NA

Abpro Bio

Celltrion

License to ABP102, the T cell engaging bispecific antibody targeting HER2 and CD3 against HER positive cancers

Precl

WW

1 750

NA

NA

Lava Therapeutics

Seagen

License to LAVA-1223, EGFR targeting bispecific T cell engager activating Vy9Vδ2 T cells against EGFR+ tumors

Precl

WW

700

50

650

Good Therapeutics

Roche

Acquisition of company developing conditionally activated cytokine programs with lead PD1 dependent IL2

Precl

NV

NA

250

NA

Scribe Therapeutics

Sanofi

License to CasX-Editor technology for multiple undisclosed oncology targets in engineered NK cell therapies

Res

WW

1 025

25

1 000

Arsenal Biosciences

Genentech

License to develop T-Cell based therapies using Arsenal’s platform of PrimeR, CARchitecture and CellFoundry

Res

WW

NA

70

NA

NASDAQ Initial Public Offerings (IPOs) in oncology

Company

Ticker

Lead product

Technology

Stage

Amount m$

Price $

bioAffinity Technologies

BIAF

Cypath

Diagnostic tests and therapies to detect and treat NSCLC at the cellular level

Market

7.86

6.13

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