PPF Group | June 2025 Biotechnology: Review of news from the most innovative therapeutic areas and the business development transactions

Market

President Trump wants interest rate cut to 1% and would “love” if Fed’s Powell resigned

US stocks took a breather end of June as the tenuous Israel-Iran cease fire continued to hold. Fed Chair Jerome Powell said inflation in goods prices is expected to go up due to Trump's tariffs. Trump said he wants interest rate cut to 1% and that he would “love” if Powell resigned.

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Antibody-Drug Conjugates

FDA approved Datroway for patients with pre-treated advanced EGFR-mutated NSCLC

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Interleukin-15 and Interleukin-2

Rezpegaldesleukin meets primary and key secondary endpoints in REZOLVE-AD Phase 2

Nektar announced statistically significant data from the 16-week induction period of the ongoing Phase 2b REZOLVE-AD study of investigational rezpegaldesleukin, an IL-pathway agonist and regulatory T-cell (Treg) proliferator.

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Cell Therapies

JNJ's dual-targeting CAR-T shows first encouraging results in large B-cell lymphoma

BMS announced that FDA approved label updates for both of its CAR T cell therapies, Breyanzi (liso-cel) for the treatment of large B cell lymphoma (LBCL) and other lymphomas and Abecma (ide-cel) for the treatment of multiple myeloma. These label updates reduce certain patient monitoring requirements and remove the Risk Evaluation and Mitigation Strategy (REMS) programs that had been in place since each product was initially approved.

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June 2025 Biotechnology: Review of news from the most innovative therapeutic areas and the business development transactions

President Trump wants interest rate cut to 1% and would “love” if Fed’s Powell resigned

FDA approved Datroway for patients with pre-treated advanced EGFR-mutated NSCLC

Rezpegaldesleukin meets primary and key secondary endpoints in REZOLVE-AD Phase 2

JNJ's dual-targeting CAR-T shows first encouraging results in large B-cell lymphoma

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