Dear customer, we are sorry but your browser doesn't support all necessary features for good site view. Please switch to one of the modern browsers (Chrome, Safari, Firefox).

NBI is down 25 % since September, number of IPOs are down to a trickle

Sotio Biotech

15/5/2022 | 4 minutes to read

Print
Copy link

The NBI added 5 % during March, however it is still down 25 % since September. Most of 2021’s biotech IPO class is trading below listing price; some biotechs are now worth no more than their cash. So far this year, IPOs are down to a trickle or being pulled, investors are cautious.

Monthly market moves of selected competitors compared to NASDAQ Biotechnology Index (NBI)

Area

Company

Ticker

Price range $

Δ Price

MktCap $m

ΔMktCap $m

ADC

ADC Therapeutics

ADCT

13.28 – 16.56

-11

%

1 150

-146

Immunogen

IMGN

4.26 – 5.64

-15

%

964

-164

Mersana Therapeutics

MRSN

3.84 – 4.68

-15

%

287

-50

Seagen

SGEN

126.68– 144.05

11

%

26 340

2 668

IL15 / 2

Alkermes

ALKS

23.18 – 27.99

10

%

4 254

385

ImmunityBio

IBRX

5.22 – 6.77

-14

%

2 231

-374

Nektar Therapeutics

NKTR

4.16 – 11.05

-51

%

995

-1 032

Xencor

XNCR

26.68 - 31.16

-14

%

1 560

-246

CAR-T

Allogene Therapeutics

ALLO

7.65 – 10.04

6

%

1 298

74

Autolus Therapeutics

AUTL

3.52 – 4.39

12

%

304

33

Bellicum Pharma

BLCM

1.48 – 2.16

37

%

18

5

Mustang Bio

MBIO

0.73 – 1.14

18

%

94

14

Other

Arcus Biosciences

RCUS

31.34 – 37.56

-16

%

2 217

-421

Immutep

IMMP

2.49 – 3.42

10

%

205

19

Clovis Oncology

CLVS

1.43 – 2.02

4

%

263

9

ADC Therapeutics

ADCT reported Q4 and annual financial results. Net loss was $34 million, or a net loss of $0.45 per share, for the quarter, and $230 million, or a net loss of $3 per share, for the full year 2021. This compares to a net loss of $56 million for the same quarter in 2020 and a net loss of $246 million for the full year 2020.

Immunogen

ImmunoGen submitted BLA under the accelerated approval pathway to the US FDA for mirvetuximab soravtansine monotherapy in patients with folate receptor alpha (FRα)-high platinum-resistant ovarian cancer who have been previously treated with 1 to 3 prior systemic treatments. The submission is based on results from the pivotal Phase 3 SORAYA trial.

Mersana Therapeutics

Mersana presented an analysis based on the June 10th, 2021 data cut from the expansion cohort of the company’s Phase 1 trial of upifitamab rilsodotin at SGO Meeting on Women’s Cancer. The data highlighted the compound’s robust clinical activity and differentiated safety profile which further support design of ongoing UPLIFT registrational trial in platinum-resistant ovarian cancer.

Seagen

Seagen and Sanofi today announced an exclusive collaboration agreement to design, develop, and commercialize ADCs for up to three cancer targets. The collaboration will utilize Sanofi’s proprietary monoclonal antibody technology and Seagen’s proprietary ADC technology.

Alkermes

The short interest of Alkermes decreased in March by 23 % to 9,030,611 on March 15, compared to 11,675,403 on February 15.

ImmunityBio

The short interest of ImmunityBio increased in March by 14 % to 16,670,227 on March 15, compared to 14,565,139 on February 15.

Nektar Therapeutics

Nektar announced an update following the first analysis of the Phase 3 PIVOT IO-001 study evaluating the doublet therapy of bempeg in combination with Opdivo compared to Opdivo monotherapy as a first-line treatment for previously untreated unresectable or metastatic melanoma. The study did not meet the primary endpoints of PFS and ORR as assessed by Blinded Independent Central Review.

Xencor

Xencor presented preclinical data on two novel XmAb cytokine programs at the AACR meeting. The company reported data of its LAG3-targeted IL15/IL15Rα-Fc fusion proteins for preferential TIL expansion, and that its engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP.

Allogene Therapeutics

Allogene announced that the FDA has granted Fast Track designation to its first AlloCAR T solid tumor clinical candidate, ALLO-316. The designation is granted to the candidate as a potential treatment for patients with advanced or metastatic clear cell RCC. Allogene is currently evaluating ALLO-316 in a phase 1 study for treating advanced or metastatic clear cell RCC.

Autolus Therapeutics

Autolus announced that EMA has granted obe-cel, Autolus’ leading CAR T clinical candidate, Orphan Medical Product Designation for treatment of ALL patients. Recruitment is ongoing in the Phase 2 portion of the pivotal study of obe-cel and we look forward to announcing first Phase 2 data this year.

Bellicum Pharmaceuticals

Bellicum reported net income of $3 million and a net loss of $10 million for 4Q and full year 2021, respectively, compared to net income of $19 million and a net loss $8 million for 4Q and full year 2020, respectively.

Mustang Bio

Mustang reported net loss of $66.4 million, or $0.76 per share, for the full year 2021, compared to a net loss attributable to common stockholders of $60 million, or $1.14 per share, for 2020.

Arcus Biosciences

Arcus announced initial PK/PD data for AB521, Arcus’s HIF-2a inhibitor, in healthy volunteers confirms its potential to have an improved clinical profile compared to that of the only approved HIF-2a inhibitor.

Immutep

Immutep announced new interim data in 2nd line metastatic NSCLC from its Phase 2 TACTI-002 trial evaluating eftilagimod alpha with pembrolizumab in a total of 36 patients with PD-L1 unselected 2nd line PD-X refractory metastatic NSCLC. The new data reflects the first interim results combining Stages 1 (23 patients) and 2 (13 patients) in 2nd line NSCLC.

Clovis Oncology

Clovis announced positive topline data from the monotherapy arm of Phase 3 ATHENA-MONO trial of Rubraca as first-line maintenance treatment in ovarian cancer. Rubraca achieved the primary endpoint of significantly improved PFS compared with placebo (20.2 months vs. 9.2 months). The median PFS for the HRD-positive patient population treated with rucaparib was 28.7 months vs. 11.3 months among those who received a placebo.

Share on social networks

Share on social networks

Print

Copy link