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SOTIO expands its ADC pipeline with collaboration and license agreement with LegoChem

Sotio

30/12/2021 | 3 minutes to read

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SOTIO Biotech announced an exclusive, target-specific license and option agreement with LegoChem Biosciences. SOTIO will obtain rights to deploy LegoChem’s ADC technology for up to five therapeutic programs targeting distinct tumor-associated antigens.The deal enables SOTIO to combine its proprietary antibodies with LegoChem’s ADC technology platform in order to deliver novel therapeutics for the treatment of solid tumors and includes LegoChem’s proprietary conjugation technology ConjuAll and potent linker-payload platform including multiple different payloads.LegoChem is eligible to receive upfront and potential milestone payments worth up to $1027.5 million, payable based on certain developments and regulatory achievements, plus royalties on net sales. The deal includes upfront and near-term milestones worth up to $29.5 million, subject to exercise of the options and achievement of success-based milestones.SOTIO will be responsiblefor R&D,manufacturing,andcommercializationof the ADC products, while LCB will support and work closely with SOTIO for the research activities and the manufacturing of components that are specifically related to its proprietary ConjuAll and the linker-payload technologies.

PARTNERING

Antengene partners with Legochem Biosciences to co-develop ADCs

Antengene announced that it has entered into a Research Collaboration and license option agreement with LegoChem for new ADCs. The two parties will jointly generate and evaluate ADC candidates using Antengene’s antibodies and LegoChem’s next generation ADC technology platform. Antengene will have an exclusive option to license global rights for the development and commercialization of the resulting ADC candidates. When the option is exercised, LegoChemwill be eligible to receive upfront and milestone payments, as well as tiered royalties. In addition, LegoChem is eligible to receive a prespecified percentage of any sublicensing income received by Antengene.

Gilead exercised its options to three Arcus’ clinical programs and adds research collaboration

Gilead has exercised its options to three programs in Arcus’s clinical-stage portfolio, including both anti-TIGIT molecules, domvanalimab and AB308, as well as etrumadenant and quemliclustat. The companies also added a research collaboration as described below.Arcus will receive option payments totaling $725 million. The parties will co-develop and share the global costs related to these programs. If the optioned molecules achieve regulatory approval, Gilead and Arcus will co-commercialize and equally share profits in the U.S. Gilead will hold exclusive rights outside the U.S., subject to any rights of Arcus’s existing collaboration partners, and Gilead will pay to Arcus tiered royalties.

Elicera Therapeutics enters agreement with BioNTech

Elicera Therapeutics’ push to develop novel immuno-oncology therapies just received a significant boost. The company has entered into a collaboration with the German contract development and manufacturing organisation BioNTech for the development of viral vectors to be used in Elicera’s ELC-401 project. Elicera expects to initiate a Phase 1/2 trial with the CAR T-cell candidate in glioblastoma multiforme patients during the second half of 2023.

Cytovia and Cellectis add new CAR targets under their existing collaboration in China

Cytovia Therapeutics and Cellectis expanded their existing partnership to include new CAR target and development in China by Cytovia’s joint venture firm, Cytolynx Therapeutics Hong Kong. The latest deal amended financial terms for the partnerships. Cellectis will have an equity stake of $20 million in Cytovia, and will receive up to $805 million in development, regulatory and sales milestones, plus single-digit royalty payments on net sales. The collaboration expansion will enable Cytovia to develop induced pluripotent stem cell (iPSC)-derived NK (iNK) products that will leverage the high-precision of transcription activator-like effector nuclease (Talen) to perform gene-editing to minimize the risk of off-target effects and unlock the full potential of NK cells as a first line of defense against cancer. Cytovia uses custom Talen developed by Cellectis to edit iPSCs. Cytovia is responsible for differentiating and expanding the gene-edited iPSC master cell bank into NK cells. It is also running the preclinical evaluation, clinical development and commercialization of selected therapeutic candidates. With the global license now including China, Cytovia can modify NK cells to address gene targets for therapeutic use in several cancer indications. Cytovia develops allogeneic off-the-shelf gene-edited iNK, as well as CAR NK cells derived from iPSCs and NK cell engager multifunctional antibodies.

Overview of transactions in oncology (values in m$)

Source

Partner

Product

Stage

Rights

Value

UF

MS

Blueprint Medicines

Zai Lab

License to EGFR family tyrosine kinase receptor inhibitor BLU-945 and BLU-701 against non-small cell lung cancer

Ph 1/2

CN,HK, TW,MC

615

25

590

Hanmi   Pharma

Aptose Biosciences

License to myeloid kinome inhibitor HM-43239 developed against acute myelogenous leukemia

Ph 1/2

WW

420

13

408

Voronoi

Pyramid Biosciences

License to monopolar spindle 1 inhibitor VRN-08 and second undisclosed asset against breast cancer

Precl

WW

846

NA

NA

Shanghai Pharma

Huya Bioscience

License to anti-tumor small molecule chemical drug SPH-6162 against cancer indications

Precl

Ex-CN,       HK,TW,      MC

298

NA

NA

LegoChem Biosciences

Sotio Biotech

Exclusie license and option agreement to deploy ConjuAll for up to 5 programs targeting tumor-associated antigens

Res

NV

1,028

30

998

Nykode Therapeutics

Regeneron

Multiproduct deal to develop vaccines for cancer and infectious diseases through modular vaccine platform

Res

WW

925

50

875

Cytovia Therapeutics

Cellectis

Induced pluripotent stem cell-derived NK products against cancer indications

Res

WW

825

20

805

NASDAQ Initial Public Offerings (IPOs) in oncology

Company

Ticker

Lead product

Technology

Stage

Amount m$

Price $

LianBio

LIAN

Infigratinib (BridgeBio)

FGFR kinase inhibitor against cholangiocarcinoma

Phase 3

325.0

16

IO Biotech

IOBT

IO102-IO103

dual IDO/PD-L1 derived peptide vaccine against melanoma

Phase 2

100.1

14

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