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Sotio Biotech

Sotio Biotech

SOTIO Biotech Group, operating within PPF Group’s biotech arm, researches and develops innovative targeted cancer therapies and applies its scientific knowledge to clinical trials. Teams of leading experts from all over the world work for SOTIO as part of its extensive international activities.

Contacts

SOTIO Biotech a.s.
P
+420 224 175 111
E
sotio@sotio.com
www.sotio.com

​​​​​​​Českomoravská 2532/19b
190 00 Prague Prague 9
Czech Republic

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Sotio Biotech B.V.

Zuidplein 168
1077 XV Amsterdam
The Netherlands

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PPF Biotech B.V.

Zuidplein 168
1077 XV Amsterdam
The Netherlands

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Related

Sotio Biotech

21/2/2023

Developing a biotech company in Central Europe is an extremely bold move, says Sotio CEO

Sotio Biotech

8/12/2021

SOTIO Announces Clinical Collaboration with MSD to evaluate IL-15 Superagonist, SOT101, in Combination with KEYTRUDA® (pembrolizumab) in Patients with Solid Tumors

SOTIO Biotech, a clinical stage immuno-oncology company owned by PPF Group, announced today that it has entered into a clinical trial collaboration and supply agreement with MSD, a tradename of Merck & Co., Inc., Kenilworth, NJ., through its subsidiaries, to evaluate the combination of SOT101, SOTIO’s IL-15 superagonist, and MSD’s KEYTRUDA® (pembrolizumab) in patients with selected advanced/refractory solid tumors in the phase 2 AURELIO-04 study.

Sotio Biotech

2/12/2021

SOTIO Secures €280m of Funding to Expand and Advance Clinical Pipeline

SOTIO Biotech, a clinical stage immuno-oncology company owned by PPF Group, announced today that is has secured €280m of funding to significantly expand and advance its clinical pipeline, including its lead asset SOT101, an IL-15 superagonist, and three new clinical programs until end of 2023.

Sotio Biotech

16/11/2021

SOTIO Expands its Antibody-Drug Conjugate Pipeline with Exclusive Collaboration and License Agreement with LegoChem Biosciences

SOTIO Biotech, a clinical stage immuno-oncology company owned by PPF Group, today announced an exclusive, target-specific license and option agreement with LegoChem Biosciences Inc. (LCB, KOSDAQ: 141080), a biotechnology company focused on developing its clinical-stage platform technology enabling antibody-drug conjugates (ADCs) with an excellent therapeutic index. SOTIO will obtain rights to deploy LCB’s ADC technology for up to five therapeutic programs targeting distinct tumor-associated antigens.

Sotio Biotech

12/11/2021

SOT101 Shows Clinical Benefit in Patients with Advanced Solid Tumors

SOTIO Biotech, a clinical stage immuno-oncology company owned by PPF Group, today announced new data from the ongoing Phase 1/1b AURELIO-03 study of SOT101, an IL-15 superagonist, as a monotherapy and in combination with pembrolizumab in patients with advanced/metastatic solid tumors. The data are presented in three posters at the Society for Immunotherapy of Cancer (SITC) 36th Annual Meeting from November 10-14, 2021.

Sotio Biotech

17/6/2021

Index of Cancer Preparedness: The Czech Republic ranks eighth in preparedness for the treatment of cancer

The Czech Republic ranks eighth among 29 countries assessed for the quality of their measures for cancer prevention and treatment. PPF and SOTIO initiated the country’s participation in the Index of Cancer Preparedness (ICP) designed by The Economist Intelligence Unit.

Sotio Biotech

10/12/2020

Acquisition agreement with Boehringer Ingelheim for NBE-Therapeutics marks first major biotech exit for PPF Group

PPF Group, an international investment group, today announced the signing of a binding agreement to sell its stake in NBE-Therapeutics to Boehringer Ingelheim.

"SOTIO exemplifies the world-class standard of Czech science in its mission and results. Our efforts are focused on finding a cure for cancer."

Radek Špíšek

CEO, SOTIO Biotech

SOTIO, part of PPF Group since 2012, coordinates the Group’s biotechnology activities. It is building a diversified portfolio of oncology programmes based on in-house research and development, partnerships, licensing agreements, investments, mergers, and acquisitions. It has operations in Europe and the US, with principal centres in Prague, Basel, and Boston. SOTIO Group, which has its own scientific and laboratory facilities in Prague, is the largest privately funded research endeavour in the Czech Republic.

Sotio

SOTIO’s research and development programmes embrace next-generation antibody-drug conjugate (ADC) oncology products, personalised cellular immunotherapy based on the CAR-T platform, and IL–15 superagonist-based treatments, including immunocytokines.

Since 2012, SOTIO has been validating the safety and efficacy of its products in comprehensive clinical trials conducted in Europe and the US.

In January 2025, SOTIO expanded its licensing collaboration with Biocytogen, a global biotechnology company advancing the research and development of novel antibody‑based therapies through innovative technologies. The company also exercised an option with Synaffix, a biotech firm offering a clinical‑stage platform for best‑in‑class antibody‑drug conjugates, bispecific antibodies, and other targeted therapeutics. This agreement further broadened the partnership to include two additional bispecific ADC candidates in SOTIO’s development pipeline.

SOTIO researchers presented promising preclinical results from two new attractive ADC programmes – SOT106 and SOT109 – at the prestigious annual conference of the American Association for Cancer Research (AACR). The company expects both programmes to advance to the clinical phase in 2026.

Other PPF Biotech Holdings

Autolus Therapeutics

Autolus Therapeutics is a leader in the development of treatments based on CAR-T cells (genetically engineered T cells). The company is dedicated to the clinical development of a wide portfolio of next-generation T-cell therapies targeting both hematological and solid tumors. www.autolus.com     

Cellestia Biotech

Cellestia Biotech was founded in 2014 as a spin-off of the Swiss Federal Institute of Technology Lausanne (EPLF). Cellestia’s lead development compound is CB-103, a novel, first-in-class oral pan-NOTCH inhibitor with an innovative mode of action meant for the treatment of patients with NOTCH-driven lymphomas and solid tumors. www.cellestia.com
Sotio Biotech